Molecular Formula | C19H19N3O6 |
Molar Mass | 385.37 |
Density | 1.3937 (rough estimate) |
Melting Point | 148-150°C |
Boling Point | 511.83°C (rough estimate) |
Flash Point | 267.8°C |
Solubility | DMSO: soluble15mg/mL, clear |
Vapor Presure | 6.94E-11mmHg at 25°C |
Appearance | powder |
Color | white to beige |
Merck | 14,6545 |
Storage Condition | Keep in dark place,Sealed in dry,2-8°C |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
Refractive Index | 1.5900 (estimate) |
Physical and Chemical Properties | Yellow prismatic crystals were obtained from ethanol with a melting point of 148-150 °c. ()-configuration:[α]D 20 222.42 °(C = 1, methanol). (-)-configuration:[α]D20-219.62. (C = 1, methanol). |
In vitro study | Nilvadipine strongly inhibits the chemotaxis of interleukin-1 (IL-1), leukotriene B4(LTB4), and platelet-derived growth factor (PDGF) in rat aortic smooth muscle cells (SMC), the IC50 was 0.1 nM. In the isolated kidney perfused with hydronephrosis, Nilvadipine increased renal blood flow and decreased filtration fraction, which indirectly dilated the afferent and efferent arterioles. |
In vivo study | In RCS rats, Nilvadipine preserves initial stage retinal morphology and electrograph response. Nilvadipine significantly enhanced rhodopsin kinase and alphaA Crystal expression and inhibited caspase 1 and 2 expression in RCS rat retinal nerve. Nilvadipine completely inhibited Aβ-induced vasoactivity in rat aorta and human brain. Nilvadipine restored cortical perfusion levels similar to control mice and did not affect CBF in control mice. Nilvadipine inhibits ischemia (20 min)-reflux (20 min)-induced paw edema in mice (ED30:0.4 mg/kg I. V. And 2 mg/kg, P. O.). Nilvadipine inhibited carrageenan-induced paw edema (ED30 15 mg/kg in rats and 20 mg/kg in mice) with potency consistent with that of the anti-inflammatory drug ibuprofen. In rats, Nifedipine, nicardipine and nimodipine at 100 mg/kg oral administration inhibited 30%. Nilvadipine inhibits the superoxide anion radical (xanthine oxidase XOD produces oxygen), both with the LDH method and the cytochrome C method (IC 50 and 90 100 mg/ml, respectively). |
Hazard Symbols | Xn - Harmful |
Risk Codes | 22 - Harmful if swallowed |
WGK Germany | 3 |
RTECS | US7968300 |
Toxicity | LD50 oral in rat: 1560mg/kg |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.595 ml | 12.975 ml | 25.949 ml |
5 mM | 0.519 ml | 2.595 ml | 5.19 ml |
10 mM | 0.259 ml | 1.297 ml | 2.595 ml |
5 mM | 0.052 ml | 0.259 ml | 0.519 ml |